Based on the panel data of all cities and states in Guizhou Province from 2010 to 2019, this paper uses the DEA-BCC model and Malmquist index to conduct a static and dynamic analysis of the efficiency of tourism economy in Guizhou Province under the background of the opening of High-speed railway (HSR). The research results are as follows: the opening of HSR has not yet become a key factor in the improvement of tourism efficiency in Guizhou Province; the promotion effect of HSR on the efficiency of tourism economy has been delayed; the opening of HSR has broken the balance of resource input and caused resource waste; taking HSR is the rigid demand to people in Guizhou Province, rather than the income level of residents.